Marc den Hartog is the CEO of ChainCraft, a Dutch biotechnology company using fermentation to convert agricultural waste into medium-chain fatty acids—essential building blocks for everything from fats for foods to lubricants to bioplastics and fragrances. Founded as a spin-off from Wageningen University, ChainCraft is pioneering open-culture fermentation process that offers a scalable, circular alternative to petroleum-based chemicals.

Lori Rosenkopf, author of Unstoppable Entrepreneurs: 7 Paths for Unleashing Successful Startups and Creating Value through Innovation, explores how success doesn’t have to mean dropping out of college to start a venture-backed unicorn in your garage. Instead, she highlights seven distinct paths that entrepreneurs can take to build impactful ventures.

Meet Ana Pavlovic, CEO of Eion and the self-described “Crazy Rock Lady.” Her company is pioneering a process called enhanced rock weathering, which uses the natural properties of a green volcanic mineral called olivine to pull carbon dioxide out of the air and lock it away—permanently.

Palm oil is everywhere—from food to cosmetics to biofuels—but its production is a leading cause of deforestation, habitat destruction, and greenhouse gas emissions. What if we could have all the benefits of palm oil without the downsides?

Enter NoPalm Ingredients, a Dutch biotech startup using fermentation to produce a sustainable alternative to palm oil—without the need for palm trees.

In this episode, Patrick and I have a wide-ranging conversation about topics like synthetic biology, science fiction, nature vs. nurture, and of course, how his company’s tech will both make money and make the world a better place. Already the company has raised more than $20 million in venture capital, with more still yet to come.

In this episode we’re diving deep into the fascinating world of carbon recycling with a trailblazer who’s reshaping how we think about waste and sustainability. Our guest is Dr. Jennifer Holmgren, CEO of LanzaTech—a company on a mission to transform our biggest environmental challenge into an economic opportunity.

Eric Schulze loves the intersection of science and food so much that after many years as an FDA regulator, he decided in 2016 to leave the federal government to join the then-nascent Memphis Meats (now UPSIDE Foods). He’d go on to spend the next seven years working to advance the cultivated meat pioneer’s science, technology, communications, and ultimate regulatory approval by the agency for which he used to work.

We all know chocolate is sweet. The way that it’s made—not so much. From deforestation and climate change to child labor and heavy metal contamination, cocoa farming leaves a lot to be desired. But what if we could make cocoa powder without having to chop down the rainforest and engage in so many other unsavory practices?

You’ve heard of fruit leather, but what about making leather from fruit? Or more precisely, feeding fruit waste like mango pulp to bacteria which then convert those sugars into a leather-like material that can be useful for all types of purposes?

Alt-meat today is typically made from soybeans, yellow peas, wheat, or some combination of those three crops. But there’s a whole world of plants out there, and maybe some of them can be harnessed to widen the world of ingredients available to manufacturers, perhaps even offering better functionality and flavor.

Isha has been pioneering cellular agriculture since 2009, driven by a passion to see transformative technology create a better world. In 2010, Isha published "Possibilities for an in-vitro meat production system" in Innovative Food Science and Emerging Technologies; thus began her quest to establish the field of cell ag.

In 2013, Dr. Mark Post shocked the world when he debuted the world’s first-ever burger grown from animal cells. Weighing in as a quarter-pounder, the burger carried a price tag of a mere $330,000—all of which was funded by Google co-founder Sergey Brin. A decade later, what does Mark think about the movement and the industry he helped birth?

In this episode, I talk with Noa about how she thinks AI can be harnessed to make better-textured alternative meat, why she started GreenProtein AI, and where she plans to go next in her promising career. We even talk about sentience, from insects to machines!

Reefgen CEO Chris Oakes, a marine biologist turned venture capitalist turned entrepreneur talks about the company’s trajectory, its pilot trials in Hawaii, California, Indonesia, and Wales, and how it’s going to scale in order to turn the tides for our planet.

In this episode, we talk with Sublime Systems co-founder Leah Ellis about her effort to decarbonize cement production for which she’s already raised $50 million.

Lisa Nunez Safarian leads commercial, manufacturing, and product development at Pivot Bio. Dedicating her career to advancing agriculture and helping farmers achieve better outcomes, Lisa oversees the day-to-day operations to ensure we are meeting the nitrogen needs of our customers.

After getting a grant from the UK government, Mira’s new company Biophilica was born. Converting leaves and even agricultural byproducts into a plastic-free alt-leather, Biophilica’s material creation process uses less than 1 percent of the water needed to make cow-based leather, all while being both animal-free and petrochemical free, too.

Rotem Cahanovitc is a mycology enthusiast innovating the use of fungi, the great recyclers of the planet, to support the transition to a flourishing, sustainable circular economy.

What started with a small grant from the National Science Foundation to two twin scientist sisters is now a startup employing dozens of people that’s so far raised more than $13 million to decarbonize how we make materials.

Luke Iseman is cofounder of Make Sunsets, a startup that launches reflective clouds to fight global warming. They have deployed over 3000 ton-years worth of cooling for paying customers, and their mission is to Cool Earth by 1C before 2030.