Seth Goldman started his career three decades ago thinking that if he wanted to make an impact on public health and agricultural sustainability, he’d need to explore a career in nonprofits or public policy. Fast forward to today and Seth’s company, Honest Tea, has helped slash billions of sugar calories from the American diet, caused other major drink brands to do the same, and created a sustainable livelihood for organic tea farming families throughout Asia.

As a student, John Mackey was an idealistic hippie who worked in a vegetarian co-op while studying religion and philosophy. He never took a business class during his whole academic career. In other words, he wasn’t exactly the guy people would’ve placed bets on to become a businessman, let alone one who’d launch a natural foods empire called Whole Foods Market that would get purchased by Amazon for $14 billion. (Note: John long ago stopped taking a salary and even donated all of his Whole Foods stock, so he didn’t see a penny of the sale.)